Article
Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma.
The Journal of pathology - 1 Jun 2011
Al-Ahmadie Hikmat A, Iyer Gopa, Janakiraman Manickam, Lin Oscar, Heguy Adriana, Tickoo Satish K, Fine Samson W, Gopalan Anuradha, Chen Ying-bei, Balar Arjun, Riches Jamie, Bochner Bernard, Dalbagni Guido, Bajorin Dean F, Reuter Victor E, Milowsky Matthew I, Solit David B
Abstract excerpt
FGFR3 mutations are common in low-grade urothelial carcinoma and represent a potential therapeutic target in this disease. Their incidence and functional role in high-grade urothelial carcinoma (HGUC), which displays an increased propensity for recurrence and muscularis propria invasion, is less well defined. We developed a mass spectrometry-based genotyping assay to define the incidence of FGFR3 mutations in a...
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