Association of PON1 Haplotypes (Q192R and L55M) with the Severity of Coronary Atherosclerosis.

doi:10.3390/ijms27167241

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Article

Association of PON1 Haplotypes (Q192R and L55M) with the Severity of Coronary Atherosclerosis.

International journal of molecular sciences - 14 Aug 2026

Rychlik-Sych Mariola, Barańska Małgorzata, Dudarewicz Michał, Owczarek Jacek

Abstract excerpt

Enzyme paraoxonase 1 (PON1) plays a protective role against atherosclerosis by preventing the oxidation of low-density lipoproteins (LDL). Polymorphisms in the PON1, particularly Q192R and L55M, have been shown to affect the enzyme activity and, consequently, the cardiovascular risk. The present study aimed to evaluate the association between PON1 haplotypes comprising the Q192R and L55M polymorphisms and the...

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PMID: 42653246
DOI: 10.3390/ijms27167241
PMCID: PMC13513132

Genes

PON1

Variants

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