Article
PON1 M/L55 mutation protects high-risk patients against coronary artery disease.
International journal of cardiology - 1 Mar 2004
Oliveira Simone A, Mansur Antonio P, Ribeiro Cristina C, Ramires José Antonio F, Annichino-Bizzacchi Joyce M
Abstract excerpt
The paraoxonase (PON) gene family contains at least three members: PON1, PON2, and PON3. The enzyme PON1 has been implicated in the pathogenesis of atherosclerosis. Recently, an association between PON2 and quantitative metabolic phenotypes, such as plasma lipoproteins, plasma glucose, and coronary artery disease (CAD), has been reported. We analyzed two common polymorphisms in PON1 (i.e., M/L55 and R/Q 192...
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