Article
Effects of α-Synuclein on the Lipid Phenotype of SZ95 Human Sebocytes: A Preliminary Study in the Context of Parkinson's Disease.
Cells - 21 Aug 2026
Mosca Sarah, Bottillo Grazia, Flori Enrica, Kovacs Daniela, Maiellaro Miriam, Lozzi Francesca, Cavallo Alessia, Zouboulis Christos C, Simmini Giulia, Luppino Alessia, Novello Claudia, Leta Valentina, Gaudiano Gianfranco, Devigili Grazia, Eleopra Roberto, Tagliavini Fabrizio, Mazzetti Samanta, Camera Emanuela, Cardinali Giorgia
Abstract excerpt
Pathological aggregation of α-synuclein (αSyn) is a hallmark of Parkinson's disease (PD), but increasing evidence indicates that αSyn deposits extend beyond the central nervous system to peripheral tissues, including the skin. In PD patients, cutaneous αSyn accumulation has been associated with seborrheic dermatitis (SD), a chronic inflammatory condition linked to sebocyte dysfunction and altered sebum...
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