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Article

Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guérin (BCG) tuberculosis vaccine substrain Tokyo-172.

Scientific reports - 4 Dec 2015

Wada Takayuki, Maruyama Fumito, Iwamoto Tomotada, Maeda Shinji, Yamamoto Taro, Nakagawa Ichiro, Yamamoto Saburo, Ohara Naoya

Abstract excerpt

BCG, only vaccine available to prevent tuberculosis, was established in the early 20th century by prolonged passaging of a virulent clinical strain of Mycobacterium bovis. BCG Tokyo-172, originally distributed within Japan in 1924, is one of the currently used reference substrains for the vaccine. Recently, this substrain was reported to contain two spontaneously arising, heterogeneous subpopulations (Types I and...

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Identifiers

PMID: 26635118
DOI: 10.1038/srep17827
PMCID: PMC4669467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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