Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study.

doi:10.1055/a-2313-9979

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Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study.

Pharmacopsychiatry - 1 Sept 2024

Islam Farhana, Lisoway Amanda, Oh Edward S, Fiori Laura M, Magarbeh Leen, Elsheikh Samar S M, Kim Helena K, Kloiber Stefan, Kennedy James L, Frey Benicio N, Milev Roumen, Soares Claudio N, Parikh Sagar V, Placenza Franca, Hassel Stefanie, Taylor Valerie H, Leri Francesco, Blier Pierre, Uher Rudolf, Farzan Faranak, Lam Raymond W, Turecki Gustavo, Foster Jane A, Rotzinger Susan, Kennedy Sidney H, Müller Daniel J

Abstract excerpt

INTRODUCTION: Little is known about the interplay between genetics and epigenetics on antidepressant treatment (1) response and remission, (2) side effects, and (3) serum levels. This study explored the relationship among single nucleotide polymorphisms (SNPs), DNA methylation (DNAm), and mRNA levels of four pharmacokinetic genes, CYP2C19, CYP2D6, CYP3A4, and ABCB1, and its effect on these outcomes. METHODS: The...

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PMID: 38917846
DOI: 10.1055/a-2313-9979

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