Article

Microbiota alterations in proline metabolism impact on depression through GABA and ECM homeostasis

2021-03-01

Abstract excerpt

<title>Abstract</title> <p>The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied a multi-omics approach combining pre-clinical models with three human cohorts including mil...

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Literature Corpus work: cea6b945-a929-58ec-bab1-427609b624c1
DOI: 10.21203/rs.3.rs-251090/v1

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