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Systems Biology of Gut Microbiome Dysbiosis in Major Depressive Disorder: Functional Microbial Networks Linked to Inflammation, Illness Severity, Recurrence, and Suicidal Behavior

2026-08-18

Abstract excerpt

<title>Abstract</title> <p>Background Major depressive disorder (MDD) is characterized by disruptions in neuroimmune, metabolic, and oxidative stress (NIMETOX) pathways, which are influenced by leaky gut. Most microbiome studies in MDD focused on taxonomic differences rather than systems biology analyses of functional microbial pathways. Methods This cross-sectional study included 102 MDD inpatients and 38 heal...

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Literature Corpus work: 041fa809-2584-532f-a763-fcd75d83ff81
DOI: 10.21203/rs.3.rs-10598930/v1

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