Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington's disease.

Bioinformatics (Oxford, England) - 1 Aug 2026

van Beek Daan, Iyer Aishwarya, Ehrhart Friederike, Evelo Chris T, de Kok Theo M, Arts Ilja C W, Adriaens Michiel E, Kutmon Martina

Abstract excerpt

MOTIVATION: Huntington's disease (HD) exhibits substantial variability in age of onset and disease progression that is not fully explained by CAG repeat length alone. Part of this residual variation is heritable, implicating additional genetic mechanisms. cis-regulatory variation, genetic variants that alter transcription and splicing of nearby genes, represents one such mechanism that can be quantified through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Regulatory Networks

Share to Huntington Disease

Share to Protein Interaction Maps

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 42635204
DOI: 10.1093/bioinformatics/btag592
PMCID: PMC13501290

Genes

FAM181B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington's disease.PMID 42635204Read ↗

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s diseaseSemantic proximity Read ↗

Proteomic profiling of baseline CSF and serum from HDClarity identifies signatures for Huntington disease staging and stratificationSemantic proximity Read ↗

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brainSemantic proximity Read ↗

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.Semantic proximity Read ↗

A common gene expression signature in Huntington’s disease patient brain regionsSemantic proximity Read ↗

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte stateSemantic proximity Read ↗

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood biomarkers in Huntington’s diseaseSemantic proximity Read ↗

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington diseaseSemantic proximity Read ↗

Identification of Novel Biomarkers in Huntington’s Disease Based on differential Gene Expression Meta-Analysis and Machine Learning ApproachSemantic proximity Read ↗

Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.Semantic proximity Read ↗

Comparative Huntington and Parkinson Disease mRNA Analysis Reveals Common Inflammatory ProcessesSemantic proximity Read ↗

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.