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Article

Darwinian Evolution of Self-Replicating DNA in a Synthetic Protocell.

Nature communications - 22 Oct 2024

Abil Zhanar, Restrepo Sierra Ana María, Stan Andreea R, Châne Amélie, Del Prado Alicia, de Vega Miguel, Rondelez Yannick, Danelon Christophe

Abstract excerpt

Replication, heredity, and evolution are characteristic of Life. We and others have postulated that the reconstruction of a synthetic living system in the laboratory will be contingent on the development of a genetic self-replicator capable of undergoing Darwinian evolution. Although DNA-based life dominates, the in vitro reconstitution of an evolving DNA self-replicator has remained challenging. We hereby...

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Identifiers

PMID: 39433731
DOI: 10.1038/s41467-024-53226-0
PMCID: PMC11494085

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