Prognostic significance of positive margin-informed tumor status in esophageal squamous cell carcinoma using next-generation sequencing.

doi:10.1093/oncolo/oyag337

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Article

Prognostic significance of positive margin-informed tumor status in esophageal squamous cell carcinoma using next-generation sequencing.

The oncologist - 6 Aug 2026

Lu Di, Tong Yu, He Chunhong, Chen Zhiming, Wang Zhizhi, Liu Jingwen, Yin Jiani C, Li Shaobin, Mai Shijie, Rao Xuguang, Cai Kaican

Abstract excerpt

BACKGROUND: Reliable prognostic biomarkers are urgently needed for operable esophageal squamous cell carcinoma (ESCC), as conventional histopathology often fails to detect minimal residual disease and accurately predict patient outcomes. PATIENTS AND METHODS: This study investigated the mutational patterns in ESCC and the prognostic value of shared mutations between tumors and margins (margin-informed tumor, MiT)...

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Topics

Humans
Prognosis
Esophageal Squamous Cell Carcinoma
High-Throughput Nucleotide Sequencing
Esophageal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Female

Mutation

Male

Middle Aged

Biomarkers, Tumor

Margins of Excision

Aged

Retrospective Studies

Carcinoma, Squamous Cell

Prospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42631685
DOI: 10.1093/oncolo/oyag337
PMCID: PMC13544954

Genes

TP53
NOTCH1

Provenance

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