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Article

Mutation-Immune Crosstalk Contextualizes CAF-Associated ARPC1A Programs and Cisplatin Response in Gastric Cancer.

Human mutation - 1 Jan 2026

Lu Deyi, Meng Fanlai, Zhou Weiying, Hu Yifei, Li Gaosha, Ge Jiahao, Zhang Qing, Min Qi

Abstract excerpt

Cisplatin response in gastric cancer is shaped by malignant cell programs, stromal states, and mutation-immune crosstalk, but the CAF subtypes linked to platinum tolerance and their epithelial effectors remain incompletely defined. We integrated single-cell RNA sequencing, epithelial CNV-like inference, fibroblast reclustering, CellChat analysis, signature scoring, hdWGCNA, CAF-epithelial coupling, exploratory...

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Topics

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to DNA Copy Number Variations

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Stomach Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 42626030
DOI: 10.1155/humu/9607360
PMCID: PMC13490708

Genes

ARPC1A
CXCL12
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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