Association of CASP10 rs13006529 with response to PEG-IFN-α-based therapy in chronic hepatitis B: Enhanced activity of caspase in HBV burden.

Abstract excerpt

BACKGROUND & AIMS: Caspase-10 (CASP10) participates in death receptor-mediated apoptosis, but the relevance of the CASP10 coding variant rs13006529 (T > A; p.Leu522Ile) to PEG-IFN-α response in chronic hepatitis B (CHB) is unknown. We assessed this association and whether differential apoptotic activity explains variant-associated HBV burden. METHODS: rs13006529 was genotyped in 262 patients receiving PEG-IFN-α...