Article
Genetic variants in the apoptosis gene BCL2L1 improve response to interferon-based treatment of hepatitis C virus genotype 3 infection.
International journal of molecular sciences - 2 Feb 2015
Clausen Louise Nygaard, Weis Nina, Ladelund Steen, Madsen Lone, Lunding Suzanne, Tarp Britta, Christensen Peer Brehm, Krarup Henrik Bygum, Møller Axel, Gerstoft Jan, Clausen Mette Rye, Benfield Thomas
Abstract excerpt
Genetic variation upstream of the apoptosis pathway has been associated with outcome of hepatitis C virus (HCV) infection. We investigated genetic polymorphisms in the intrinsic apoptosis pathway to assess their influence on sustained virological response (SVR) to pegylated interferon-α and ribavirin (pegIFN/RBV) treatment of HCV genotypes 1 and 3 infections. We conducted a candidate gene association study in a...
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