Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.

doi:10.1186/s12920-020-00760-7

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Article

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.

BMC medical genomics - 26 Aug 2020

Winkler Thomas W, Grassmann Felix, Brandl Caroline, Kiel Christina, Günther Felix, Strunz Tobias, Weidner Lorraine, Zimmermann Martina E, Korb Christina A, Poplawski Alicia, Schuster Alexander K, Müller-Nurasyid Martina, Peters Annette, Rauscher Franziska G, Elze Tobias, Horn Katrin, Scholz Markus, Cañadas-Garre Marisa, McKnight Amy Jayne, Quinn Nicola, Hogg Ruth E, Küchenhoff Helmut, Heid Iris M, Stark Klaus J, Weber Bernhard H F

Abstract excerpt

BACKGROUND: Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been uncovered, little is known about the genetic architecture of early AMD. METHODS: To identify genetic factors for early AMD, we conducted a genome-wide association study (GWAS) meta-analysis (14,034 cases, 91,214 controls, 11 sources of data including...

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Identifiers

PMID: 32843070
DOI: 10.1186/s12920-020-00760-7
PMCID: PMC7449002

Genes

APOE
ARMS2
C2
C3
CD46
CETP
CFH
HTRA1
TNFRSF10A
TYR
VEGFA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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