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Article

Integrative multiomic analysis unveils the molecular nexus of mitochondrial dysfunction in the pathogenesis of age-related macular degeneration.

Experimental eye research - 1 Dec 2024

Chen Jianqi, Liu Zhe, Zhu Yingting, Li Zhidong, Wen Yuwen, Chen Danna, Liang Jingying, Xiao Yue, Leng Yunxia, Zhuo Yehong

Abstract excerpt

Mitochondrial dysfunction is linked to age-related macular degeneration (AMD), but its mechanisms and related molecular networks remain unclear. We explored the association between mitochondrial-related genes and AMD by integrating multiomic data. We acquired summary-level data on mitochondrial-related protein abundance, gene expression, and gene methylation from quantitative trait locus studies. Genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39490725
DOI: 10.1016/j.exer.2024.110141

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