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Article

Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration.

BMC medical genomics - 6 Jul 2020

Waksmunski Andrea R, Grunin Michelle, Kinzy Tyler G, Igo Robert P, Haines Jonathan L, Cooke Bailey Jessica N

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is a progressive retinal disease contributing to blindness worldwide. Multiple estimates for AMD heritability (h2) exist; however, a substantial proportion of h2 is not attributable to known genomic loci. The International AMD Genomics Consortium (IAMDGC) gathered the largest dataset of advanced AMD (ADV) cases and controls available and identified 34 loci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32631374
DOI: 10.1186/s12920-020-00747-4
PMCID: PMC7336430

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