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Article

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross-Reactive Groups and Human Platelet Antigens.

Journal of clinical laboratory analysis - 1 Sept 2026

Ji Huimin, Feng Kaihao, Xu Yunping, Chang Le, Yan Ying, Ma Jie, Liu Yi, Zeng Jinfeng, Sun Huizhen, Wang Lunan

Abstract excerpt

BACKGROUND: Immune-mediated platelet transfusion refractoriness (IPTR) remains a major clinical challenge, with immune alloimmunization against HLA and HPA as the predominant causes. Although HLA cross-reactive groups (CREGs) provide a practical alternative to allele-level matching, methods for simultaneous HLA-CREG and HPA genotyping remain limited despite their potential to improve platelet matching. METHODS:...

Read the complete abstract on PubMed

Topics

Humans
Antigens, Human Platelet
HLA Antigens
Cross Reactions
Multiplex Polymerase Chain Reaction
Reproducibility of Results

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Platelet Transfusion

Real-Time Polymerase Chain Reaction

Limit of Detection

Alleles

Source

Open in PubMed Open full text

Identifiers

PMID: 42592787
DOI: 10.1002/jcla.70326
PMCID: PMC13470767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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