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Rapid and Robust Multiplex Multicolour Melting Curve Analysis Enables Simultaneous Detection of HLA Cross-Reactive Groups and HPA Genotypes.

HLA - 1 Mar 2026

Sun Huizhen, Su Qian, Zeng Jinfeng, Xu Yunping, Chang Le, Yan Ying, Ma Jie, Ji Huimin, Wang Lunan

Abstract excerpt

Platelet transfusion refractoriness (PTR) is a major clinical challenge that increases bleeding risk and wastes blood resources. Immune-mediated PTR is mainly caused by alloantibodies against HLA class I and human platelet antigens (HPA). To overcome this, transfusion of compatible platelets based on HLA cross-reactive groups (CREGs) and HPA genotypes is considered effective; however, current detection methods...

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PMID: 41792588
DOI: 10.1111/tan.70626

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