Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beyond HLA: an exploratory pilot study of non-HLA antibodies, HLA sensitization, and GSTT1 genotype in platelet transfusion refractoriness.

Frontiers in immunology - 1 Jan 2026

Qi Jun, Zhu Huachao, Wang Manni, Wang Tianju, Li Yuhui, Shang Lixia, Chen Le, Wang Xiaofang, Shao Jing, Ma Chaofeng, Xu Hua

Abstract excerpt

Objectives: Platelet transfusion refractoriness (PTR) is a common and clinically challenging condition with complex underlying mechanisms. Human leukocyte antigen (HLA) alloimmunization is the principal cause of immune PTR (iPTR), whereas non-HLA antibodies (non-HLA Abs) are known to contribute to antibody-mediated rejection, microvascular inflammation, interstitial fibrosis, and graft loss. However, whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to GSTT1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Glutathione Transferase

Share to HLA Antigens

Share to Isoantibodies

Share to Pilot Projects

Share to Platelet Transfusion

Source

Open in PubMed Open full text

Identifiers

PMID: 42597480
DOI: 10.3389/fimmu.2026.1886771
PMCID: PMC13469656

Genes

GSTT1
CSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beyond HLA: an exploratory pilot study of non-HLA antibodies, HLA sensitization, and GSTT1 genotype in platelet transfusion refractoriness.PMID 42597480Read ↗

[Analysis of the distribution frequencies of HLA-A and HLA-B alleles in patients with immune-mediated Platelet transfusion refractoriness].Semantic proximity Read ↗

Simultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing.Semantic proximity Read ↗

HLA-Mediated Platelet RefractorinessSemantic proximity Read ↗

[Analysis of HLA and HPA Antibody Specificity and Evaluation of HLA Antigen Immunogenicity in 90 Platelet Transfusion Refractory Patients in Changchun Region].Semantic proximity Read ↗

Back to base pairs: What is the genetic risk for red bloodcell alloimmunization?Semantic proximity Read ↗

Prevalence and risk factors of antibodies to HLA according to different cut-off values of mean fluorescence intensity in haploidentical allograft candidates: A prospective study of 3805 subjects.Semantic proximity Read ↗

Integrating HLA and HPA in Precision Transfusion: Insights from Platelet Transfusion Refractoriness Driven by Anti-CD36 Alloimmunization and Multifactorial Hemostatic ComplicationsSemantic proximity Read ↗

Platelet antigens. The role of human platelet alloantigens (HPA) in blood transfusion and transplantation.Semantic proximity Read ↗

Genetic variants of human platelet antigens in the Indian population from 1029 whole genomesSemantic proximity Read ↗

Genetic landscape of human platelet antigen variants in the Indian population analysed from 1029 whole genomes.Semantic proximity Read ↗

Impact of Red Blood Cell Antigen Matching on Alloimmunization and Transfusion Complications in Patients with Sickle Cell Disease: A Systematic Review.Semantic proximity Read ↗

Platelet transfusions in haploidentical haematopoietic stem cell allograft candidates: Protecting HLA-A and HLA-B antigens through eplet analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.