Article
Integrated Mutation Profiling and Prognostic Genomic Signature in Pediatric Testicular and Ovarian Germ Cell Tumors.
Human mutation - 1 Jan 2026
Xuan Xiaoqi, Yang Yue, Li Yongle, Yang Jinlong, Wu Hang, Gong Yulong, Li Guogen, Pu Xiao
Abstract excerpt
Background: Pediatric testicular and ovarian germ cell tumors generally have favorable outcomes, but a subset of patients experience relapse, progression, or persistent disease. Conventional risk assessment is based primarily on stage, histology, primary site, serum tumor markers, and treatment response; the incremental prognostic value of genomic profiling remains uncertain. Methods: This retrospective molecular...
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