Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors.

Nature communications - 5 May 2020

Akhavanfard Sara, Padmanabhan Roshan, Yehia Lamis, Cheng Feixiong, Eng Charis

Abstract excerpt

Compared to adult carcinomas, there is a paucity of targeted treatments for solid tumors in children, adolescents, and young adults (C-AYA). The impact of germline genomic signatures has implications for heritability, but its impact on targeted therapies has not been fully appreciated. Performing variant-prioritization analysis on germline DNA of 1,507 C-AYA patients with solid tumors, we show 12% of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Helicases
Share to Exome Sequencing
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Germ-Line Mutation

Share to Neoplasms

Share to Smad7 Protein

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 32371905
DOI: 10.1038/s41467-020-16067-1
PMCID: PMC7200683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors.PMID 32371905Read ↗

Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors.Semantic proximity Read ↗

Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis.Semantic proximity Read ↗

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.Semantic proximity Read ↗

Pediatric Cancer Genetics and Genomics.Semantic proximity Read ↗

The landscape of genomic alterations across childhood cancers.Semantic proximity Read ↗

An institutional review of genomic sequencing in pediatric solid tumors.Semantic proximity Read ↗

The role of genomic profiling in adolescents and young adults (AYAs) with advanced cancer participating in phase I clinical trials.Semantic proximity Read ↗

Cancer Predisposition Genes in Adolescents and Young Adults (AYAs): a Review Paper from the Italian AYA Working GroupSemantic proximity Read ↗

Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers.Semantic proximity Read ↗

High-Throughput Genomic Profiling of Adult Solid Tumors Reveals Novel Insights into Cancer Pathogenesis.Semantic proximity Read ↗

Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors—a nationwide, prospective Swedish studySemantic proximity Read ↗

Clinical Impact of Germline Multigene Sequencing in Pediatric Cohorts with a Wide Spectrum of Neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.