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Article

The pan-cancer landscape of prognostic germline variants in 10,582 patients.

Genome medicine - 17 Feb 2020

Chatrath Ajay, Przanowska Roza, Kiran Shashi, Su Zhangli, Saha Shekhar, Wilson Briana, Tsunematsu Takaaki, Ahn Ji-Hye, Lee Kyung Yong, Paulsen Teressa, Sobierajska Ewelina, Kiran Manjari, Tang Xiwei, Li Tianxi, Kumar Pankaj, Ratan Aakrosh, Dutta Anindya

Abstract excerpt

BACKGROUND: While clinical factors such as age, grade, stage, and histological subtype provide physicians with information about patient prognosis, genomic data can further improve these predictions. Previous studies have shown that germline variants in known cancer driver genes are predictive of patient outcome, but no study has systematically analyzed multiple cancers in an unbiased way to identify genetic loci...

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Share to Tumor Suppressor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Germ-Line Mutation

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 32066500
DOI: 10.1186/s13073-020-0718-7
PMCID: PMC7027124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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