Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG-TOP2 Study.

doi:10.1111/cas.70249

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Genomic Profiling of Pediatric Solid Tumors With a Dual DNA/RNA Panel: JCCG-TOP2 Study.

Cancer science - 1 Feb 2026

Tao Kayoko, Yoshioka Takako, Kato Miho, Komatsu Kazuyuki, Tsujimoto Shinichi, Sakamoto Kenichi, Tanimura Kazuki, Sugiyama Minako, Sekiguchi Masahiro, Nakano Yoshiko, Otani Yoshihiro, Yatabe Yasushi, Yoshida Akihiko, Okita Hajime, Hirato Junko, Kohashi Kenichi, Tanaka Yukichi, Kohsaka Shinji, Kubo Takashi, Sunami Kuniko, Hirata Makoto, Tsutsumi Shuichi, Aburatani Hiroyuki, Koh Katsuyoshi, Hirayama Masahiro, Karakawa Shuhei, Terashita Yukayo, Fujisaki Hiroyuki, Yagi Takeshi, Yoneda Akihiro, Mochizuki Shinji, Shichino Hiroyuki, Suzuki Tatsuya, Takimoto Tetsuya, Ichimura Koichi, Ogawa Chitose, Matsumoto Kimikazu, Ichikawa Hitoshi, Kato Motohiro

Abstract excerpt

To develop an optimized genomic medicine platform for pediatric cancers, a nationwide cancer genome profiling project was conducted from January 2022 to February 2023 in collaboration with the Japan Children's Cancer Group. This prospective observational study analyzed matched blood and FFPE tumor samples from patients aged 0-29 years with solid tumors. Genomic analysis used the TOP2 hybrid capture-enrichment...

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PMID: 41249692
DOI: 10.1111/cas.70249
PMCID: PMC12861092

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