Article

CRISPR/Cas9-based Editing of a Sensitive Transcriptional Regulatory Element to Achieve Cell Type-Specific Knockdown of the NEMO Scaffold Protein

2018-10-23

Abstract excerpt

<h4>ABSTRACT</h4> The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling. Transcription of the NEMO gene is primarily controlled by two promoters: one (promoter B) drives NEMO transcription in most cell types and the second (promoter A) is largely responsible for NEMO transcripti...

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Literature Corpus work: 9b5576ed-4a71-57be-99e9-dd611620f027
DOI: 10.1101/450320

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