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Article

Cross-tissue Mendelian randomization prioritizes RAB27B as a brain-derived candidate protein for postpartum depression.

European archives of psychiatry and clinical neuroscience - 1 Oct 2026

Huang Ya-Jing, Chen Ke-Wei, Xu Qiu-Han, Li Huai-Fang, Yang Yang

Abstract excerpt

OBJECTIVE: Postpartum depression (PPD) is one of the most common and debilitating complications of childbirth, yet the candidate proteins linking genetic risk to disease remain poorly defined. Building on recent genome-wide association studies (GWAS), we sought to integrate cross-tissue proteogenomic data to identify candidate proteins for PPD and explore therapeutic opportunities. METHODS: We conducted...

Read the complete abstract on PubMed

Topics

Humans
Female
Genome-Wide Association Study
Depression, Postpartum
rab GTP-Binding Proteins
Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Source

Identifiers

PMID: 42584685
DOI: 10.1007/s00406-026-02349-0

Genes

RAB27B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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