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Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood.

Molecular psychiatry - 1 Jun 2022

Deng Yue-Ting, Ou Ya-Nan, Wu Bang-Sheng, Yang Yu-Xiang, Jiang Yan, Huang Yu-Yuan, Liu Yi, Tan Lan, Dong Qiang, Suckling John, Li Fei, Yu Jin-Tai

Abstract excerpt

Genome-wide association studies (GWASs) have identified numerous risk genes for depression. Nevertheless, genes crucial for understanding the molecular mechanisms of depression and effective antidepressant drug targets are largely unknown. Addressing this, we aimed to highlight potentially causal genes by systematically integrating the brain and blood protein and expression quantitative trait loci (QTL) data with...

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PMID: 35296807
DOI: 10.1038/s41380-022-01507-9

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