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Article

MKRN1 as a prioritized drug target for postpartum depression: evidence from druggable proteome profiling and multi-layer validation.

Translational psychiatry - 10 Feb 2026

Jia Tingting, Yuan Chengsong, Hu Shiyi, Xie Liangyue, Liu Andi, Qin Fengqin, He Yongji, Zhang Chengcheng

Abstract excerpt

Postpartum depression (PPD) is a significant global health concern affecting women, yet effective and innovative therapeutic targets remain limited. Although genome-wide association studies (GWAS) have identified genetic risk loci, their underlying mechanisms and translational potential remain poorly understood. Therefore, we integrated PPD GWAS data with protein quantitative trait loci from two independent...

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Identifiers

PMID: 41667429
DOI: 10.1038/s41398-026-03886-x
PMCID: PMC12916849

Genes

MKRN1
CCDC92

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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