Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.

doi:10.1038/s41588-024-01839-y

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Article

Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.

Nature genetics - 1 Aug 2024

Westergaard David, Steinthorsdottir Valgerdur, Stefansdottir Lilja, Rohde Palle Duun, Wu Xiaoping, Geller Frank, Tyrmi Jaakko, Havulinna Aki S, Solé-Navais Pol, Flatley Christopher, Ostrowski Sisse Rye, Pedersen Ole Birger, Erikstrup Christian, Sørensen Erik, Mikkelsen Christina, Bruun Mie Topholm, Aagaard Jensen Bitten, Brodersen Thorsten, Ullum Henrik, Magnus Per, Andreassen Ole A, Njolstad Pål R, Kolte Astrid Marie, Krebs Lone, Nyegaard Mette, Hansen Thomas Folkmann, Feenstra Bjarke, Daly Mark, Lindgren Cecilia M, Thorleifsson Gudmar, Stefansson Olafur A, Sveinbjornsson Gardar, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Banasik Karina, Jacobsson Bo, Laisk Triin, Laivuori Hannele, Stefansson Kari, Brunak Søren, Nielsen Henriette Svarre

Abstract excerpt

Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal-fetal health. We identified five genetic loci linked to PPH in a meta-analysis. Functional annotation analysis indicated candidate genes HAND2, TBX3 and RAP2C/FRMD7 at three...

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Identifiers

PMID: 39039282
DOI: 10.1038/s41588-024-01839-y
PMCID: PMC11319197

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