Article
Brain proteome-wide association study implicates novel proteins in depression pathogenesis.
Nature neuroscience - 1 Jun 2021
Wingo Thomas S, Liu Yue, Gerasimov Ekaterina S, Gockley Jake, Logsdon Benjamin A, Duong Duc M, Dammer Eric B, Lori Adriana, Kim Paul J, Ressler Kerry J, Beach Thomas G, Reiman Eric M, Epstein Michael P, De Jager Philip L, Lah James J, Bennett David A, Seyfried Nicholas T, Levey Allan I, Wingo Aliza P
Abstract excerpt
Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization. We identified 19 genes that were consistent with being...
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