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Article

Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma.

International journal of surgery (London, England) - 1 Dec 2025

Zhang Yajie, Li Yang, Huang Wentao, Tong Shuangshuang, Zeng Ruijie, Lyu Yanlin, Leung Felix W, Chen Kequan, Sha Weihong, Chen Hao

Abstract excerpt

BACKGROUND: Gastroesophageal reflux disease (GERD) and asthma are commonly co-occurring conditions, with shared genetic factors identified. However, the specific loci and the influence of common genetic architecture remain undefined. METHODS: We obtained genome-wide association study (GWAS) summary statistics for GERD (71 522 cases and 261 079 controls) and asthma (56 167 cases and 352 255 controls). Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40932390
DOI: 10.1097/JS9.0000000000003283
PMCID: PMC12695380

Genes

MPHOSPH9
RBM6
SUOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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