TP53 status is associated with differential stress-marker expression and APP maturation in colon cancer cells.

Abstract excerpt

BACKGROUND: The systemic influence of tumor-derived secretomes on the nervous system remains poorly understood. We investigated whether differences in TP53 status are associated with altered cellular stress-handling states and amyloid precursor protein (APP) processing in colon cancer cells. METHODS: APP maturation, intracellular localization, and stress-associated signaling were analyzed in TP53 wild-type and...

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