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Genetic Diversity and Haplotype Architecture of Non-Classical HLA Class I Genes in the Japanese Population.

HLA - 1 Aug 2026

Ito-Naito Ikue, Khor Seik-Soon, Sato Tetsuya, Wakabayashi Shunichi, Kinoshita Daisuke, Kubo Naoya, Omae Yosuke, Tokunaga Katsushi, Hayashi Hiroshi

Abstract excerpt

The non-classical Class I genes (HLA-E, HLA-F and HLA-G) show limited protein-level diversity; however, full-length analyses that include regulatory and noncoding regions have not been sufficiently performed in East Asian populations. We designed new primers for long-range PCR and conducted PacBio SMRT sequencing to generate full-length gene sequences of HLA-E, HLA-F and HLA-G, including 5' and 3' untranslated...

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Identifiers

PMID: 42576171
DOI: 10.1111/tan.70898
PMCID: PMC13457674

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