Article
Catalog of 162 single nucleotide polymorphisms (SNPs) in a 4.7-kb region of the HLA-DP loci in southern Chinese ethnic groups.
Journal of human genetics - 1 Jan 2004
Liu Xiaoyi, Liu Zehuan, Lin Bin, Liu Yuanyuan, Chen Zhuoxun, He Weicong, Zhong Dong, Xu Anlong
Abstract excerpt
HLA class-II proteins are cell-surface molecules that present antigens to T cells, and their expressional regulation is crucial to the immune reaction. Sequence variation at the regulatory region can directly affect the gene expression level. We cloned and sequenced a 4.7-kb region containing the regulatory region, exon1, and partial intron1 of both HLA-DPA1 and DPB1 genes in 25 variable sequences from southern...
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