Correspondence: Beyond phenotypic observations: elucidating the molecular drivers of hypoxia-reoxygenation-induced aggressiveness in breast cancer.

Abstract excerpt

In their recent study, Maniar et al. demonstrated context-dependent phenotypic effects of hypoxia-reoxygenation in breast cancer cell lines [1]. These included enhanced proliferation, invasion, clonogenicity, and chemoresistance. While these findings provide important insights into tumor adaptation under fluctuating oxygen conditions, several mechanistic aspects remain insufficiently explored. In this...

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