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Article

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis.

Nature communications - 24 Oct 2019

Godet Inês, Shin Yu Jung, Ju Julia A, Ye I Chae, Wang Guannan, Gilkes Daniele M

Abstract excerpt

Hypoxia is known to be detrimental in cancer and contributes to its development. In this work, we present an approach to fate-map hypoxic cells in vivo in order to determine their cellular response to physiological O2 gradients as well as to quantify their contribution to metastatic spread. We demonstrate the ability of the system to fate-map hypoxic cells in 2D, and in 3D spheroids and organoids. We identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31649238
DOI: 10.1038/s41467-019-12412-1
PMCID: PMC6813355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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