Article
Hypoxia-reoxygenation cycle leads to context dependent phenotypic effects in breast cancer cell lines.
Molecular biology reports - 10 Jun 2026
Maniar Jinesh, Dhas Pranali, Datt Pulkit, Dange Prerana, Gandhi Khushboo A, Bhatia Dimple, Chaubal Rohan, Gardi Nilesh, Kembhavi Yogesh, Joshi Shalaka, Badwe Rajendra, Gupta Sudeep
Abstract excerpt
BACKGROUND: Hypoxia is a common feature of solid tumors and is associated with cancer progression. We investigated the effect of hypoxia followed by reoxygenation on the phenotypic behavior of two breast cancer cell lines, MCF-7 and MDA-MB-231. METHODS AND RESULTS: MCF-7 and MDA-MB-231 cells were exposed to controlled hypoxia (1% O2, 1 h and 24 h) followed by reoxygenation (24 h to 96 h) and compared to their...
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