Article

Complex Karyotype and TP 53 Alterations in AML and MDS

2026-06-30

Abstract excerpt

<h4>Background: </h4> /Objectives: A complex karyotype (CK) in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) is defined as the presence of three or more unrelated chromosomal abnormalities in the absence of defining core-binding factor translocations. Frequently involved chromosomes include losses/deletions on chromosomes 5, 7 and 17. It is heavily associated with TP53 mutations, with 70-80% of...

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Literature Corpus work: 3145e4ff-765a-521c-bf94-288134eb0ef8
DOI: 10.20944/preprints202606.2212.v1

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