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Article

TP53 Amplification, a Rare but Recurrent Alteration in Myeloid Neoplasms.

Genes, chromosomes & cancer - 1 Jul 2026

Stengel Anna, Meggendorfer Manja, Haferlach Torsten, Walter Wencke

Abstract excerpt

The tumor suppressor gene TP53 is a key regulator of genomic stability, frequently altered across human cancers. In hematologic malignancies, TP53 lesions-typically mutations, deletions, and copy-neutral loss of heterozygosity-are associated with complex karyotypes, therapy resistance, and dismal prognosis. Amplifications of TP53, however, have not been systematically described in this context. We retrospectively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42478550
DOI: 10.1002/gcc.70154
PMCID: PMC13386404

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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