Article
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome.
Blood - 1 Mar 2012
Rücker Frank G, Schlenk Richard F, Bullinger Lars, Kayser Sabine, Teleanu Veronica, Kett Helena, Habdank Marianne, Kugler Carla-Maria, Holzmann Karlheinz, Gaidzik Verena I, Paschka Peter, Held Gerhard, von Lilienfeld-Toal Marie, Lübbert Michael, Fröhling Stefan, Zenz Thorsten, Krauter Jürgen, Schlegelberger Brigitte, Ganser Arnold, Lichter Peter, Döhner Konstanze, Döhner Hartmut
Abstract excerpt
To assess the frequency of TP53 alterations and their correlation with other genetic changes and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed integrative analysis using TP53 mutational screening and array-based genomic profiling in 234 CK-AMLs. TP53 mutations were found in 141 of 234 (60%) and TP53 losses were identified in 94 of 234 (40%) CK-AMLs; in total, 164 of 234 (70%)...
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