Article
Associations of Age With Tumor Genomic Characteristics in Relapsed/Refractory Cancers Interrogated With the NCI-MATCH Trial Targeted Gene Panel Assay.
JCO precision oncology - 1 Aug 2026
Sankaran Hari, Kotliarov Yuri, Zhao Yingdong, Harris Lyndsay N, Tricoli James V, Hamilton Stanley R, Temkin Sarah M, Karlovich Chris, Chang Ting-Chia, Wang Victoria, Gray Robert J, Wei Zihan, Shin Sarah J, Seibel Nita L, Das Biswajit, Coffey Brent, Patton David, Li Ming-Chung, Li Jessica, Best Ana F, Williams P Mickey, Iafrate A John, Sklar Jeffrey, Flaherty Keith T, Chen Alice P, O'Dwyer Peter J, McShane Lisa M
Abstract excerpt
PURPOSE: Motivated by the rising incidence of cancers at younger ages, this study compares tumor genomic alterations between adolescents and young adults (AYAs; 18-39 years) and non-AYAs (40 years and older) and explores the relationship with continuous age in patients with relapsed/refractory ovarian, breast, and colorectal cancers accrued to the NCI-MATCH trial. METHODS: Tumor genomic profiles generated by a...
Topics
- Humans
- Female
- Age Factors
- Adult
- Male
- Young Adult
- Adolescent
- Ovarian Neoplasms
- Neoplasm Recurrence, Local