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Clinical application of genomic profiling to find druggable targets for adolescent and young adult (AYA) cancer patients with metastasis.

BMC cancer - 29 Feb 2016

Cha Soojin, Lee Jeongeun, Shin Jong-Yeon, Kim Ji-Yeon, Sim Sung Hoon, Keam Bhumsuk, Kim Tae Min, Kim Dong-Wan, Heo Dae Seog, Lee Se-Hoon, Kim Jong-Il

Abstract excerpt

BACKGROUND: Although adolescent and young adult (AYA) cancers are characterized by biological features and clinical outcomes distinct from those of other age groups, the molecular profile of AYA cancers has not been well defined. In this study, we analyzed cancer genomes from rare types of metastatic AYA cancers to identify driving and/or druggable genetic alterations. METHODS: Prospectively collected AYA tumor...

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Chromosomal Instability
Cyclin-Dependent Kinase Inhibitor p18
Drug Discovery
INDEL Mutation
Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins, Fusion

Receptors, Notch

Wnt Signaling Pathway

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Identifiers

PMID: 26925973
DOI: 10.1186/s12885-016-2209-1
PMCID: PMC4772349

Genes

FAT1
NOTCH1
ALK
EML4
KRAS
MDM2
PTEN
RASA2
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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