Article
Multi-dimensional analysis of adult acute myeloid leukemia cross-continents reveals age-associated trends in mutational landscape and treatment outcomes (Acute Myeloid Leukemia Cooperative Group & Alliance for Clinical Trials in Oncology).
Leukemia - 1 Dec 2025
Cusan Monica, Larkin Karilyn, Nicolet Deedra, Jurinovic Vindi, Mrózek Krzysztof, Batcha Aarif M N, Rothenberg-Thurley Maja, Schneider Stephanie, Sauerland Cristina, Görlich Dennis, Krug Utz, Berdel Wolfgang E, Woermann Bernhard J, Hiddemann Wolfgang, Braess Jan, Spiekermann Karsten, Greif Philipp A, Blachly James S, Mims Alice S, Walker Christopher J, Walker Michael C, Oakes Christopher C, Orwick Shelley, Carroll Andrew J, Blum William G, Powell Bayard L, Kolitz Jonathan E, Moore Joseph O, Mayer Robert J, Larson Richard A, Stone Richard M, Byrd John C, Metzeler Klaus H, Herold Tobias, Eisfeld Ann-Kathrin
Abstract excerpt
The outcome of patients with acute myeloid leukemia (AML) worsens with increasing age. Dichotomization into "younger" and "older" patients is clinically routine and often dictates treatment options. We aimed to delineate whether molecular genetic features and/or outcome measures support assorting patient populations by age, including division into "younger" and "older" groups. We analyzed 2823 adult AML patients...
Topics
- Humans
- Leukemia, Myeloid, Acute
- Middle Aged
- Adult
- Male
- Female