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Article

Hyperpolarized [2-13C]Pyruvate Identifies a Mitochondria-Active Hepatocellular Carcinoma Phenotype With Vulnerability to Mitochondrial Inhibition.

NMR in biomedicine - 1 Sept 2026

Dou Qianhui, Mirrione Sophia M, Santos Karen Dos, Calos Samuel R, Grant Aaron K, Yen Yi-Fen, Tsai Leo L

Abstract excerpt

Hepatocellular carcinoma (HCC) exhibits metabolic heterogeneity that is not fully characterized by glycolysis-focused spectroscopic profiling. This study investigated whether in vitro hyperpolarized (HP) [2-13C]pyruvate NMR spectroscopy can identify a mitochondria-active HCC phenotype and assess its association with sensitivity to mitochondrial metabolic inhibition. HP [2-13C]pyruvate NMR spectroscopy was used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42554299
DOI: 10.1002/nbm.70360
PMCID: PMC13439720

Genes

HP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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