Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.

Mitochondrion - 1 Nov 2012

Kami Kenjiro, Fujita Yasunori, Igarashi Saori, Koike Sayaka, Sugawara Shoko, Ikeda Satsuki, Sato Naomi, Ito Masafumi, Tanaka Masashi, Tomita Masaru, Soga Tomoyoshi

Abstract excerpt

Pyruvate treatment was found to alleviate clinical symptoms of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome and is highly promising therapeutic. Using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS), we measured time-changes of 161 intracellular and 85 medium metabolites to elucidate metabolic effects of pyruvate treatment on cybrid human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Capillary

Share to Energy Metabolism

Share to MELAS Syndrome

Share to Metabolome

Share to Pyruvic Acid

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 22884939
DOI: 10.1016/j.mito.2012.07.113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.PMID 22884939Read ↗

Integrated Proteomic and Metabolomic Analyses of the Mitochondrial Neurodegenerative Disease MELASSemantic proximity Read ↗

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.Semantic proximity Read ↗

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutationSemantic proximity Read ↗

Metabolic impact of pathogenic variants in the mitochondrial glutamyl-tRNA synthetase EARS2.Semantic proximity Read ↗

Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cellsSemantic proximity Read ↗

Metabolomic and Mitochondrial Fingerprinting of the Epithelial-to-Mesenchymal Transition (EMT) in Non-Tumorigenic and Tumorigenic Human Breast CellsSemantic proximity Read ↗

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.Semantic proximity Read ↗

Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I.Semantic proximity Read ↗

Hyperpolarized [2-13C]Pyruvate Identifies a Mitochondria-Active Hepatocellular Carcinoma Phenotype With Vulnerability to Mitochondrial Inhibition.Semantic proximity Read ↗

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.Semantic proximity Read ↗

Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts.Semantic proximity Read ↗

4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.