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Article

STK11 c.1062 C > G germline variant in medullary thyroid carcinoma: implications for familial predisposition and genetic counseling.

Endocrine - 3 Aug 2026

Kong Weimao, Bao Longnv, Wang Meili, Zhao Xiangzhong, Gu Haiyan, Pan Xingzhu, Zhang Xinyi, Zhang Tingling, Xing Xiaoming, Wang Jigang

Abstract excerpt

PURPOSE: Medullary thyroid carcinoma (MTC) is characterized by frequent RET mutations, while non-RET alterations remain less well studied. Previous reports have identified a recurrent STK11 c.1062 C > G (p.Phe354Leu) variant in MTC, but its clinicopathologic and functional significance remains uncertain. METHODS: A total of 129 MTCs (128 families) were analyzed by Sanger sequencing to screen for the STK11...

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Source

Identifiers

PMID: 42545603
DOI: 10.1007/s12020-026-04729-x

Genes

STK11
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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