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Article

Four novel RET germline variants in exons 8 and 11 display an oncogenic potential in vitro.

European journal of endocrinology - 1 Apr 2010

Muzza Marina, Cordella Daniela, Bombled Johny, Bressac-de Paillerets Brigitte, Guizzardi Fabiana, Francis Zelia, Beck-Peccoz Paolo, Schlumberger Martin, Persani Luca, Fugazzola Laura

Abstract excerpt

CONTEXT: Most germline-activating mutations of the RET proto-oncogene associated with inherited medullary thyroid cancer (MTC) are localized in exons 10, 11 and 13-15. Four novel RET variants, located in the extracellular domain (p.A510V, p.E511K and p.C531R) coded by exon 8 and in the intracellu...

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Source

Identifiers

PMID: 20103606
DOI: 10.1530/EJE-09-0929

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20103606-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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