Article
Lack of concordance between residual viremia and viral variants driving de novo infection of CD4(+) T cells on ART.
Retrovirology - 2 Aug 2016
Puertas Maria C, Noguera-Julian Marc, Massanella Marta, Pou Christian, Buzon Maria J, Clotet Bonaventura, Stevenson Mario, Paredes Roger, Blanco Julià, Martinez-Picado Javier
Abstract excerpt
BACKGROUND: In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. Although residual viremia might be associated with increased chronic immune activation and morbidity, its origin and its potential role in the...
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