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Article

HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers

19 Jul 2018

Abstract excerpt

HIV posttreatment controllers (PTCs) represent a natural model of sustained HIV remission, but they are rare and little is known about their viral reservoir. We obtained 1,450 proviral sequences after near-full-length amplification for 10 PTCs and 16 posttreatment noncontrollers (NCs). Before treatment interruption, the median intact and total reservoir size in PTCs was 7-fold lower than in NCs, but the...

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PMID: 30024859
DOI: 10.1172/jci120549

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