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Article

Plasma metabolite octadecadienedioate: A novel protective factor against diabetes-related Charcot foot.

Medicine - 31 Jul 2026

Zhou Daosen, Xie Diya, Yang Lihang, Li Cheng, Liu Fengmin

Abstract excerpt

Charcot foot (CF) is a severe, progressive neuro-osteoarthropathy predominantly affecting diabetic patients with peripheral neuropathy. Characterized by progressive bone and joint destruction, CF can lead to debilitating foot deformities, ulceration, infection, and ultimately lower extremity amputation. Despite its significant clinical impact, the global prevalence remains uncertain, with an estimated 1.6 million...

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PMID: 42536514
DOI: 10.1097/MD.0000000000049973
PMCID: PMC13433017

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